Endocrine Abstracts

Background and aim: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionary conserved and widely distributed throughout organism. Broad interest for AIP comes from involvement of loss-of-function AIP mutations in pituitary adenoma pathogenesis. The role of AIP in normal pituitary function is largely unknown. AIP is co-localized with GH in somatotroph secretory vesicles. Serum AIP protein was proteomically identified. We aimed at investigating whether AIP and GH are...

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...

40-year-old female patient presented with acromegaly in 2008 (GH 61 (g/L, IGF-1 774 ng/ml PRL 1500 mU/L). Macro-adenoma invading the right cavernous sinus was found on MRI and she underwent two pituitary surgeries revealing sparsely granulated GH adenoma with scattered PRL cells, low Ki 67 and negative p53 immuno-staining. Her second cousin was treated for macro prolactinoma. Both patients tested negative for germline mutations in the AIP and menin genes. Treatment with somato...

Objective: Hypopituitarism is a rare disease,a pituitary adenoma and is treatment being the most common cause of it. In recent years there is increased reporting of rare causes of hypopituitarism acquired in adulthood, such as other sellar and parasellar masses, brain damage caused by radiation and traumatic brain injury (TBI), vascular lesions, infiltrative/immunological/inflammatory diseases and infectious diseases. Aim of our study was to increase the awareness to these rar...

Introduction: Maternal thyroid hormone during early pregnancy is important for proper fetal growth and development. Thyroid hormone receptors are widely expressed in placental tissue. Interestingly, thyroid dysfunction and suboptimal placental function have both been associated with pregnancy complications including preeclampsia, premature delivery and fetal growth restriction. First, we studied the association of the maternal thyroid and placental function and second, we inve...

Objective: Congenital hypogonadotropic hypogonadism (CHH) results from isolated GnRH deficiency and may present with normal sense of smell (nCHH), anosmia (Kallmann syndrome, KS) or in syndromic forms. Genetic defects are identified in approximately half of CHH cases and oligogenicity is noted in almost 10%. Further, spontaneous reversal of is seen in 15% of patients.Methods: We analyzed the clinical characteristics of 37 Serbian CHH probands (34 sporadi...

There are different explanations concerning observed improvement of glucose control after baiatric gatric bypass surgery. The aim of our study was to investigate GLP-1 response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5; 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase) and GLP-1 (Active 7-36) (pM/l; ELISA, ALPCO diagnostics) were determined in 41 obese patients (age: 37.86...

Introduction: Different surgical procedures are followed by alteration in insulin sensitivity. The aim of our investigation was to analysed the influence of major (open cholecystectomy) and minor surgical stress (laparoscopic cholecystectomy) on insulin resistance.Methods: Insulin resistance was calculated by HOMA-IR before surgery and at 1st, 3rd, and 7th day after the elective operations. All participants were divided in two groups: group A with open c...

Bariatric surgery, especially malapsorptive procedures like gastric bypass, can lead to anaemia due to lack of iron absorption as well as vitamins essential for the normal functioning of the hematopoietic system.Methods: We have analysed changes in red blood cells (RBC), haemoglobin (Hb), white blood cells (WBC), serum iron (Fe), and vitamin B12 3 years after gastric bypass in 142 morbidly obese patients (female, n=108 and male, n=34). ...

Introduction: Obesity is a risk factor for the development of insulin resistance, type 2 diabetes, cardiovascular diseases and non-alcoholic fatty liver disease. The aim of our study was to examine predictive value of liver enzymes in assessing biomarkers of insulin sensitivity in obese, non-diabetic adults.Methods: 1104 obese, non-diabetic adults were included in the study. Patients were divided into two groups: Group A (BMI 30.0–39.9 kg/m2</s...